Désirée Migliaccio, born in Ischia (NA), completed her piano and high school studies before undertaking training in opera singing at the Santa Cecilia Conservatory in Rome, where she earned a master's degree in Operatic Singing and Musical Disciplines with top marks and honors. She received an honorable mention at the Castrocaro Classical Festival. «Best Graduates in Italy» and perfected her skills at the’Academy of the Maggio Musicale Fiorentino.

Winner of the First Prize at the 62nd European Community Competition for Young Opera Singers of Spoleto, he attended the advanced courses at Experimental Lyric Theatre, making his debut in the roles of Guild in Rigoletto of G. Green, Adina in the'Elixir of Love of G. Donizetti is Camilletta in Don Falcone of N. Jommelli. It later established itself at the’VIII International Competition «Ritorna Vincitor», getting the role of Violet in Traviata of G. Green, set up at the Virtual Archaeological Museum of Herculaneum.

He inaugurated the Concert Cycle «MozarTiAmo» ofRoman Philharmonic Academy in the role of Madame Herz in Der Schauspieldirektor of WA Mozart. His concert activity has extended to numerous international festivals: the VI Hermitage Music Festival of St. Petersburg, the’VIII Festival of Lyric Art of Sibiu, the XXIV International Spring Festival of Pyongyang, the Celebrations for the Year of Italy in China in Beijing and the Umbrian Musical Offering Festival in New York.

He passed the selections for Choir Artist – Soprano announced by the main Italian lyric-symphonic foundations — Academy of Santa Cecilia, San Carlo Theater, Arena of Verona, Maggio Musicale Fiorentino, Municipal Theater of Bologna is Carlo Felice Theater —, working with the major conductors, directors and singers on the international scene. He was also part of the World Youth Choir of the International Federation for Choral Music of Namur (Belgium), participating in the VI World Symposium on Choral Music from Minneapolis.

Overall winner of the competition for Choir Artist – Soprano banned in 2018 by San Carlo Theater Foundation, where she is currently employed with a permanent contract, made her debut as a soprano soloist in Carmina Burana of C. Orff, in the Stabat mater It is in the Hi Regina of GB Pergolesi, as well as in the role of the Priestess in the'Aida of G. Green.

On the recording side he has recorded Chamber Arias of Italian Belcanto for the Teatro Lirico Sperimentale and Five Miniatures for soprano and piano — in duo with the pianist Luca Iacono — on the CD Music as an idea of Umberto Rotondi, for The Musical Composition Workshop of the composer Enrico Renna. She collaborated as a soprano soloist with the composer Ennio Morricone on the international tour «Morricone directs Morricone».

He collaborates with contemporary composers and with various Italian chamber music groups, including the Royal Chapel Group of the San Carlo Theater from Naples, with a repertoire ranging from ancient and baroque music to the most recent contemporary production.